Abstract We present an interesting case of salicylism arising from the use of methyl salicylate as part of a herbal skin cream for the treatment of psoriasis. Methyl salicylate is the most poisonous form of the salicylate type of chemicals. DO NOT make the person throw up unless poison control or a health care provider tells you to. It is used in many over-the-counter products, including muscle ache creams. Call 911 for all medical emergencies. Salicylates. (2002). Meyler's Side Effects of Drugs. Methyl salicylate can be poisonous in large amounts. 204-317-7 For the full text of the H-Statements and R-Phrases mentioned … Wintergreenplants which are botanically referred to as gaultheria procumbens are the oneswhich produce methyl salicylate in significant amounts and they can always berecognized by a rather characteristic scent. Reviewed by: Jesse Borke, MD, CPE, FAAEM, FACEP, Attending Physician at Kaiser Permanente, Orange County, CA. Accidental overdose from aspirin is very uncommon in the paediatric population, but methyl salicylate overdose is associated with significant toxicity even with very small ingestions. This site complies with the HONcode standard for trustworthy health information: verify here. Methyl salicylate (oil of wintergreen) is a chemical that smells like wintergreen. 16th ed. Definition: Salicylate toxicity is characterized by a constellation of symptoms caused by acute or chronic overdose of salicylate containing compounds. This can be followed by an anion gap metabolic acidosis due to the accumulation of organic acids. This article is for information only. Aspirin and nonsteroidal agents. Hyperpnea is an early finding of toxicity, as salicylates can act directly on the medullary respiratory center leading to hyperventilation leading to a respiratory alkalosis. Warning! This can be by accident or on purpose. Methyl salicylate (oil of wintergreen) is a chemical that smells like wintergreen. Toxic ingestions of salicylates typically occur with doses of approximately 150 mg/kg body weight. Take the container with you to the hospital, if possible. Below are symptoms of a methyl salicylate overdose in different parts of the body. U.S. Department of Health and Human Services, Eye irritation -- burning, redness, tearing, pain, light sensitivity, Loss of vision (from ulcers of the cornea), Coma (decreased level of consciousness and lack of responsiveness), Name of the product (ingredients and strength, if known), ECG (electrocardiogram, or heart tracing), Medicine to reverse stomach inflammation and bleeding, breathing problems, and other symptoms, Tube through the mouth into the stomach if vomiting contains blood, Breathing support, including tube through the mouth into the lungs and connected to a breathing machine (ventilator). Waltham, MA: Elsevier; 2016:293. A.D.A.M. DO NOT use it to treat or manage an actual overdose. Even if this study has not been performed according to standard guideline, it provides information on the absence of toxicity at the concentration tested. In: Aronson JK, ed. All local poison control centers in the United States use this national number. … Rosen's Emergency Medicine: Concepts and Clinical Practice. The onset of chronic salicylate poisoning may be insidious. If you or someone you are with has an overdose, call your local emergency number (such as 911), or your local poison center can be reached directly by calling the national toll-free Poison Help hotline (1-800-222-1222) from anywhere in the United States. is among the first to achieve this important distinction for online health information and services. Methyl salicylate is easily characterized by a high degree of toxicity. 16th ed. This substance has caused adverse reproductive and fetal effects … How well someone does depends on how much salicylate is in the blood and how quickly treatment is received. 4; H302 <= 100 % EC-No. Philadelphia, PA: Elsevier; 2018:chap 144. Deep heating rubs overdose; Oil of wintergreen overdose. Synonyms : 2-Hydroxybenzoic acid methyl ester Oil of wintergreen Wintergreen oil Methyl 2-hydroxybenzoate Formula : C8H8O3 Molecular weight : 152.15 g/mol CAS-No. They will give you further instructions. The presence of methyl salicylate in this plant confirms the ethno medicinal importance of L. aestuans. A single teaspoon (5 ml) of methyl salicylate contains approximately 6 g of salicylate, which is equivalent to almost twenty 300 mg aspirintablets (5 ml × 1.174 g/ml = 5.87 g). The provider will measure and monitor the person's vital signs, including temperature, pulse, breathing rate, and blood pressure. It is used in many over-the-counter products, including muscle ache creams. Medicinal products Methyl salicylate has anti-inflammatory properties and is still used, A study in 4 human volunteers (Wolowich, 2003) gave a mean time to maximum serum concentration of salicylate of 2.4 hours, confirming the slower absorption in humans reported by Davison … The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. Methyl salicylate (oil of wintergreen) is a chemical that smells like wintergreen. Methyl salicylate exposure in toddlers Serious toxicity can result from exposure to small amounts of methyl salicylate. The acid-base disorders with salicylate intoxication are very interesting. Because methyl salicylate’s main metabolite is salicylic acid, salicylate toxicity was considered. Little acute toxicity (LD(50) in rats; >2 g/kg) via a dermal exposure route is seen for Salicylic Acid, Methyl Salicylate, Tridecyl Salicylate, and Butyloctyl Salicylate. At the hight dose This is a free and confidential service. In a 2-year toxicity study in rat, methylsalicylic acid was given at dietary concentrations of 0, 0.1, 0.5, 1 and 2%, corresponding to doses of 0, 50, 250, 500 and 1000 mg/kg bw. May cause central nervous system effects. 9th ed. Ingestion is the most common route of both accidental and intentional exposures to all types of salicylates. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. All local poison control centers in the United States use this national number. Editorial team. You can call for any reason, 24 hours a day, 7 days a week. Methyl salicylate CAS-No. It does NOT need to be an emergency. 9th ed. Also reviewed by David Zieve, MD, MHA, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. According to WebMD, methyl salicylate is found in many topical ointments bought over the counter for minor joint aches or muscular pains. Even mild salicylic acid toxicity can present with symptoms such as Has wintergreen character floral and fruity. How to use Methyl Salicylate 10 %-Menthol 3 % Topical Patch. The ester is potentially the most toxic salicylate for infants and children, as 4 ml can be fatal (Davison et al., 1961; Jacobziner, 1963). DO NOT make the person throw up unless poison control or a health care provider tells you to. URAC's accreditation program is an independent audit to verify that A.D.A.M. The site is secure. It is used in many over-the-counter products, including muscle ache creams. 119-36-8 METHYL SALICYLATE >99% 204-317-7 Section 3 - Hazards Identification EMERGENCY OVERVIEW Appearance: colorless to yellow-red liquid. The absolute level should not detract from the importance of careful and repeated clinical evaluation. Seek medical help right away. Index-No. It does NOT need to be an emergency. This is a free and confidential service. The faster the medical help is given, the better the chance is for recovery. Brine shrimp toxicity test Methyl salicylate overdose occurs when someone swallows a dangerous amount of a product containing this substance. In: Aronson JK, ed. Hatten BW. Deep heating rubs overdose; Oil of wintergreen overdose. Applies to methyl salicylate topical: external cream, external gel, external liquid, external lotion, external oil, oil. This can be by accident or on … New York Eye and Ear Infirmary of Mount Sinai, The Blavatnik Family – Chelsea Medical Center, Heart - Cardiology and Cardiovascular Surgery, Mount Sinai – Sema4 Health Discovery Initiative Patient Opt Out Registry, Eye irritation -- burning, redness, tearing, pain, light sensitivity, Loss of vision (from ulcers of the cornea), Coma (decreased level of consciousness and lack of responsiveness), Name of the product (ingredients and strength, if known), ECG (electrocardiogram, or heart tracing), Medicine to reverse stomach inflammation and bleeding, breathing problems, and other symptoms, Tube through the mouth into the stomach if vomiting contains blood, Breathing support, including tube through the mouth into the lungs and connected to a breathing machine (ventilator). They will give you further instructions. The most common salicylate is aspirin, but the group also includes topical forms of salicylates, methyl salicylate (Oil of Wintergreen), and bismuth subsalicylate (such … A.D.A.M., Inc. is accredited by URAC, for Health Content Provider (www.urac.org). Methyl salicylate overdose occurs when someone swallows a dangerous amount of a product containing this substance. This can be by accident or on … Groups of 10 males and 10 females were fed 0, 0.1 and 1.0 per cent. It can also be found in intimate products. To use the sharing features on this page, please enable JavaScript. Rosen's Emergency Medicine: Concepts and Clinical Practice. Copyright 1997-2020, A.D.A.M., Inc. Most people can recover if the effect of the salicylate can be stopped. Methyl salicylate is the most poisonous form of the salicylate type of chemicals. Your local poison control center can be reached directly by calling the national toll-free Poison Help hotline (1-800-222-1222) from anywhere in the United States. This national hotline will let you talk to experts in poisoning. It is related to aspirin. Causes eye and skin irritation. The Council of Europe publications “Plants in Cosmetics Volume III” (2006) and “Active ingredients in cosmetics: safety survey” (2008) present more details. 3.2. Bell AJ, et al. This progressive acidosis can promote the influx of salicylic acid into the cent… Methyl salicylate overdose occurs when someone swallows a dangerous amount of a product containing this substance. Your local poison control center can be reached directly by calling the national toll-free Poison Help hotline (1-800-222-1222) from anywhere in the United States. Methyl salicylate is potentially deadly, especially for young children. It can be concluded that salicylate is distributed widely in the body after administration of MeS and other salicylates. You should call if you have any questions about poisoning or poison prevention. Salicylate toxicity continues to be seen in the emergency department as a result of unintentional ingestions or suicide attempts. Endoscopy, or passing a tube with a camera through the mouth into the stomach, may be needed to stop internal bleeding. Waltham, MA: Elsevier; 2016:293. If the burning sensation is painful or causes significant discomfort, wash the treated skin area with soap and cool water. WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a … Methyl salicylate is extracted from essential oil of Wintergereen oil, Ylang ylang oil and Acacia oil. It is used in many over-the-counter products, including muscle ache creams. Updated by: Jesse Borke, MD, CPE, FAAEM, FACEP, Attending Physician at Kaiser Permanente, Orange County, CA. If you or someone you are with has an overdose, call your local emergency number (such as 911), or your local poison center can be reached directly by calling the national toll-free Poison Help hotline (1-800-222-1222) from anywhere in the United States. follows rigorous standards of quality and accountability. Philadelphia, PA: Elsevier; 2018:chap 144. Aronson JK. This national hotline will let you talk to experts in poisoning. This can be … Aronson JK. How well someone does depends on how much salicylate is in the blood and how quickly treatment is received. In: Walls RM, Hockberger RS, Gausche-Hill M, eds. You can call for any reason, 24 hours a day, 7 days a week. Methyl salicylate is used to treat mild muscle / joint aches and pains (for example, arthritis, backache, sprains). Methyl salicylate overdose occurs when someone swallows a dangerous amount of a product containing this substance. Seek medical help right away. 119-36-8 Acute Tox. Chronic salicylate poisoning may cause anxiety, tachypnoea, diffuse sweating, difficulty concentrating, confusion, hallucinations and even agitated delirium. How does methyl salicylate relieve pain? Fenchol or 1,3,3-trimethyl-2-norbornanol is a terpene and an isomer of borneol and is used also in perfumery. It is related to aspirin. Definition: Salicylate toxicity is characterized by a constellation of symptoms caused by acute or chronic overdose of salicylate containing compounds. This sensation is usually mild and should gradually lessen over time. It is related to aspirin. Methyl salicylate overdose occurs when someone swallows a dangerous amount of a product containing this substance. Use this medication on the skin only. One 2002 case study reported acute toxicity in a man receiving a topical methyl salicylate treatment for psoriasis. Internal bleeding is possible, and blood transfusion may be needed. It is used in many over-the-counter products, including muscle ache creams. Methyl salicylate can cause a cold or burning sensation wherever it is applied. Endoscopy, or passing a tube with a camera through the mouth into the stomach, may be needed to stop internal bleeding. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. A licensed physician should be consulted for diagnosis and treatment of any and all medical conditions. Duplication for commercial use must be authorized in writing by ADAM Health Solutions. What are some side effects that I need to call my doctor about right away? These products contain methyl salicylate: Other products may also contain methyl salicylate. For information only -- they do NOT constitute endorsements of those other sites 10 females were fed 0, and! Of 10 males and 10 females were fed 0, 0.1 and per., notably methyl salicylate overdose in different parts of the body after administration of MeS other... 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